Effects of ginkgo biloba extract combined with glucocorticoid on olfactory function and inflammatory cytokines in mice with allergic rhinitis.
10.13201/j.issn.1001-1781.2018.02.009
- Author:
Chan WU
1
;
Yong Xiang WEI
1
;
Jayant Marian PINTO
2
;
Jun TIAN
3
;
Xian Dao YUAN
1
;
Xiao Jun ZHAN
1
Author Information
1. Department of Otolaryngology Head and Neck Surgery,Beijing Anzhen Hospital,Capital Medical University Beijing,100029,China.
2. Section of Otolaryngology-Head and Neck Surgery,Department of Surgery,The University of Chicago.
3. Department of Otolaryngology Head and Neck Surgery,Shanxi Medical University.
- Publication Type:Journal Article
- Keywords:
ginkgo biloba extract;
olfactory dysfunction;
rhinitis, allergic
- MeSH:
Animals;
Cytokines;
metabolism;
Disease Models, Animal;
Glucocorticoids;
administration & dosage;
pharmacology;
Mice;
Mice, Inbred BALB C;
Plant Extracts;
administration & dosage;
pharmacology;
Rhinitis, Allergic;
drug therapy;
immunology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2018;32(2):113-117
- CountryChina
- Language:Chinese
-
Abstract:
To determine whether ginkgo biloba extract(GBE)combined with dexamethasone(DEX)plays a role in the treatment of allergic rhinitis-related olfactory dysfunction using an animal model.Six week old BALB/C mice were sensitized and challenged with ovalbumin.30 sensitized mice were divided into three groups:Group 1 was given high-dose GBE and DEX(n=10);Group 2 was given low dose GBE and DEX(n=10);Group 3 was given DEX alone(n=10).We assessed the histology of the olfactory mucosa and serum IL-4,IFN-γ,and caspase 1.A significant higher fraction of mice in group 1 could find the food pellet within300 scompared to group 3(<0.05).Caspase-1 levels improved during the second week compared with the first week in each group.IFN-γlevels were significantly lower during the second week compared with the first week(<0.05,all).IL-4 levels also were significantly lower during the second week compared with the first week in all groups except those receiving DEX alone.IFN-γ/IL-4 levels in each group were significantly lower during the second week compared with the first week(<0.05,all).In this animal model of allergic rhinitis-related olfactory dysfunction,the addition of ginkgo biloba extract to dexamethasone have a better anti-inflammatory effect,which can partly improve the therapeutic effect on olfactory dysfunction caused by allergic rhinitis.
