Analysis of CDSS Experimental Indexes in 333 Cases of Newly Diagnosed Acute Leukemia.
10.19746/j.cnki.issn.1009-2137.2019.03.004
- Author:
Zuo-Miao XIAO
1
;
Xian-Chun CHEN
1
;
Lei ZHONG
1
;
De-Jun XIAO
1
;
Chen-Ming HE
2
;
Xiao-Zhong WANG
3
,
4
Author Information
1. Department of Clinical Laboratorial Examination，Ganzhou Hospital Affiliated to Nanchang University, Ganzhou 341000 Jiangxi Province, China.
2. Department of Hematology，Ganzhou Hospital Affiliated to Nanchang University, Ganzhou 341000 Jiangxi Province, China.
3. Department of Clinical Laboratorial Examination, The Second Hospital Affiliated to Nanchang University, Nanchang 336000, Jiangxi Province, China,E-mail:wangxzlj@
4. com.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Disseminated Intravascular Coagulation;
Hemorrhage;
Humans;
Leukemia, Myeloid, Acute;
Leukemia, Promyelocytic, Acute
- From:
Journal of Experimental Hematology
2019;27(3):652-656
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the 5 experimental indexes of CDSS in the patients with acute leukemia (AL) so as to provide the laboratorial basis for the early diagnosis and treatment of the secondary DIC in AL.
METHODS:Three hundred and thirty three patients with AL were divided into 7 groups, such as AML-M1-M5, other AML and ALL. The experimental indexes and CDSS scores of all AL groups were compared and analyzed in pairs, meanwhile 100 healthy persons were taken in the control group. Clinical events such as early death in all cases were also analyzed.
RESULTS:The highest positive rate of Platelet was 59.76%, among the 5 experimental indexes, followed by D-D (30.93%), and the lowest APTT with only 2.70%. Compared with the control group, the differences of remaining indexes were statistically significant (P＜0.01), except APTT in group AML-M3 and FIB in the other AML groups. The score of laboratory index was (1.50±1.51) in all AL patients, and the positive rate of overt DIC ( score≥4) was 14.11% ( 47 cases). The highest score of CDSS was (3.34 ±1.71) in group AML-M3. The difference in the incidence of early death and cerebral (pulmonary) hemorrhage in DIC patients were statistically significant (P＜0.05 and P＜0.01).
CONCLUSION:The application of quantitative integral method of experimental indexes in CDSS is objective and feasible, which is of great significance for early diagnosis and early treatment of acute leukemia complicated with DIC.
