CircRNA as a new field in human disease research.
10.19540/j.cnki.cjcmm.20171106.012
- Author:
Jia-Liang GAO
1
;
Guang CHEN
1
;
Hao-Qiang HE
1
;
Jie WANG
1
Author Information
1. Guang'anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053， China.
- Publication Type:Journal Article
- Keywords:
circRNA;
diagnosis;
diseases;
traditional Chinese medicine syndromes
- MeSH:
Biomarkers;
Biomedical Research;
trends;
Humans;
Medicine, Chinese Traditional;
RNA;
genetics;
Syndrome
- From:
China Journal of Chinese Materia Medica
2018;43(3):457-462
- CountryChina
- Language:Chinese
-
Abstract:
For the characteristics of high stability， high conservation between species， and tissue specificity， circular RNA(circRNA) has been expected to become a new molecular biomarker for the clinical diagnosis， treatment and prognosis， and the potential target for targeted therapy. Study on the traditional Chinese medicine(TCM) syndrome includes not only the macro indexes collected by using four traditional methods of diagnosis， but also contains some micro information that can not be achieved by using the four traditional diagnosis methods. The questions such as how to deal with the relationship between the holistic concept of TCM and micro research， and how to solve the contradiction between the fuzziness of syndrome description and the accuracy of microscopic research， need to be considered before the micro research in TCM syndrome. circRNA as a new field of understanding human disease， may provide some ideas for the TCM syndrome research due to its characteristics. Overall， it is necessary to pay attention to explore the molecular level with same syndrome in different diseases and reveal the connotation and essence of syndromes by understanding of circRNA.
