Chemical and cytotoxic constituents of Zanthoxylum nitidum.
10.19540/j.cnki.cjcmm.20180926.001
- Author:
Li-Na ZHAO
1
;
Jia WANG
1
;
Zhe WANG
1
;
Ning-Hua TAN
1
Author Information
1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
- Publication Type:Journal Article
- Keywords:
Zanthoxylum;
Zanthoxylum nitidum;
alkaloids;
cyclopeptides;
cytotoxicity
- MeSH:
Alkaloids;
Chromatography, High Pressure Liquid;
Humans;
Zanthoxylum
- From:
China Journal of Chinese Materia Medica
2018;43(23):4659-4664
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds were isolated from the methanol extract of Zanthoxylum nitidum through silica gel, Sephadex LH-20, RP-18 and HPLC chromatography techniques. Their structures were elucidated by the MS and NMR spectra as zanthonitidine B(1), cyclo-(Leu-Leu-Leu-Leu-Ile)(2),6S-10-O-demethylbocconoline(3), liriodenine(4), isoplatydesmine(5), 5, 5'-dimethoxylariciresinol(6), syringaresinol (7), episyringaresinol (8), marmesin (9) and syringaldehyde (10). Among them,1 is a new alkaloid,2 is a cyclopentapeptide isolated from plant kingdom for the first time, and 3 is from the genus Zanthoxylum for the first time. Compounds 3 and 4 exhibited cytoxoxicity against three human cancer cell lines HT29, A549 and MDA-MB-231 with IC₅₈ values of 27.37, 24.10, 33.58 μmol·L⁻¹ and 9.12,6.05, 11.35 μmol·L⁻¹, respectively.
