Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial.
10.1007/s11655-017-2960-4
- Author:
Shi-Wei LIU
1
;
Jie GUO
1
;
Wei-Kang WU
2
;
Ze-Liang CHEN
3
;
Ning ZHANG
4
Author Information
1. Department of Nephrology and Endocrinology, Wangjing Hospital, Chinese Academy of Chinese Medical Science, Beijing, 100102, China.
2. Institute of Integrative Medicine, Sun Yat-sen University, Guangzhou, 510275, China.
3. Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, 100071, China.
4. Department of Nephrology and Endocrinology, Wangjing Hospital, Chinese Academy of Chinese Medical Science, Beijing, 100102, China. znice3927@sohu.com.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
randomized control trial;
recurrent urinary tract infection
- MeSH:
Adult;
Aged;
Anti-Bacterial Agents;
therapeutic use;
Double-Blind Method;
Female;
Humans;
Medicine, Chinese Traditional;
Middle Aged;
Recurrence;
Urinary Tract Infections;
drug therapy
- From:
Chinese journal of integrative medicine
2019;25(1):16-22
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To evaluate Chinese medicine (CM) formula Bazheng Powder () as an alternative therapeutic option for female patients with recurrent urinary tract infection (RUTI).
METHODS:A randomized double-blinded trial was performed. Eligible female patients with RUTI were recruited from one hospital and two community health centers. By using a blocked randomization scheme, participants were randomized to receive a CM formula (10 herbs) for 4 weeks or antibiotics for 1 week, followed by 3 weeks of placebo. Clinical cure rate and microbiological cure and recurrence after treatment were evaluated.
RESULTS:A total 122 eligible patients were enrolled, with 61 cases in each group. The clinical cure rate by the intentto- treatment approach was 90.2% for the CM group and 82.0% for the antibiotics group (P>0.05). Bacteria were cleared from 88.5% (54/61) of patients in the CM group and 82.0% (50/61) in the antibiotics group. The recurrence rate in recovered patients at the 6-month follow-up was 9.1% (5/61) and 14.0 (7/61) in the CM and antibiotics groups, respectively (P>0.05).
CONCLUSION:CM formula Bazheng Powder is a good alternative option for RUTI treatment. (Registration No. NCT01745328).
