Causative Agents and Antimicrobial Sensitivity of Neonatal Sepsis: Ten-year Experience in One Neonatal Intensive Care Unit.
- Author:
Hye Won PARK
1
;
Gina LIM
;
So Eun KOO
;
Byong Sop LEE
;
Ki Soo KIM
;
Soo Young PI
;
Ai Rhan KIM
Author Information
1. Department of Pediatrics, Division of Neonatology, University of Ulsan College of Medicine, Childrens Hospital, Asan Medical Center, Seoul, Korea. arkim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Neonatal sepsis;
Causative organism;
Antibiotic susceptibility
- MeSH:
Amikacin;
Ampicillin;
Anti-Bacterial Agents;
Cefotaxime;
Ciprofloxacin;
Cloaca;
Coagulase;
Enterobacter;
Gram-Negative Bacteria;
Humans;
Imipenem;
Incidence;
Infant, Newborn;
Infection Control;
Intensive Care, Neonatal;
Penicillins;
Pneumonia;
Retrospective Studies;
Sepsis;
Staphylococcus
- From:Journal of the Korean Society of Neonatology
2009;16(2):172-181
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE:To identify trends in causative bacterial organisms for neonatal sepsis and antimicrobial susceptibilities over 10 years in one neonatal intensive care unit. METHODS:We retrospectively reviewed the cases of culture-proven neonatal sepsis between January 1998 and December 2007. The 10-year period was divided into two phases (phase I, 1998-2002; phase II, 2003-2007) to distinguish the differences during the entire period. RESULTS:Total 350 episodes of neonatal sepsis were identified in 315 neonates. The common pathogens of early-onset sepsis were S. epidermidis, S. aureus, P. aeruginosa, and E. cloacae in phase I, and S. epidermidis and E. cloacae in phase II. In cases of late- onset sepsis, coagulase negative Staphylococcus, S. aureus, and K. pneumoniae were isolated frequently in both phases. The incidence of sepsis caused by multi-drug resistant organisms decreased with strict infection control. Gram positive organisms showed 0-20% susceptibility to penicillin, ampicillin, and cefotaxime in both phases. Sensitivity to amikacin for Enterobacter spp. increased, whereas P. aeruginosa showed decreased sensitivity in phase II. Between 50% and 60% of other gram negative bacteria, except P. aeruginosa, were susceptible to cefotaxime in phase II in contrast to phase I. Greater than 80% of gram negative bacteria were sensitive to imipenem except P. aeruginosa and ciprofloxacin in both phases. CONCLUSION:The trend in causative microorganisms and antimicrobial susceptibilities can be used as a guideline for selection of appropriate antibiotics. A particular attention should be paid to infection control, especially to reduce sepsis caused by multi-drug resistant organisms.
