The Efficacy of Miniaturized Repetitive Transcranial Magnetic Stimulation in Patients with Depression
10.9758/cpn.2019.17.3.409
- Author:
Sangmin LEE
1
;
Kuk In JANG
;
Sejin YOON
;
Jeong Ho CHAE
Author Information
1. Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea. alberto@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Depression;
Transcranial magnetic stimulation;
Antidepressants
- MeSH:
Antidepressive Agents;
Depression;
Humans;
Transcranial Magnetic Stimulation
- From:Clinical Psychopharmacology and Neuroscience
2019;17(3):409-414
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The present study aimed to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) at a high frequency using a miniaturized device compared to standard rTMS and sham rTMS for the treatment of depression. METHODS: Fifty-four patients with depression were randomly assigned to either 15 days of miniaturized, standard, or sham rTMS. The stimulation consisted of 60 trains of 5 seconds at 10 Hz for 30 minutes. Clinical measures were assessed at baseline and on the final day of the stimulation. RESULTS: A repeated-measures analysis of variance revealed a significant main effect of time and a time by group interaction on Hamilton Rating Scale for Depression scores. There were no significant correlations between individual motor thresholds and changes of clinical outcomes. Our results revealed a significant reduction in the Hamilton Rating Scale for Depression in the miniaturized and standard groups compared to the sham group. CONCLUSION: The antidepressant utility of miniaturized rTMS using subthreshold stimulation was comparable to that of standard stimulation.
