Embryonal Carcinoma of the Pineal Gland Developed in an Adolescent Boy with Klinefelter Syndrome
10.15264/cpho.2019.26.2.105
- Author:
Hyo Jin CHOI
1
;
Eun Ah KIM
;
Jae Min LEE
;
Kyung Mi JANG
;
Joon Hyuk CHOI
Author Information
1. Department of Pediatrics, Yeungnam University Hospital, Daegu, Korea. fortune001j@gmail.com, mopic@hanmail.net
- Publication Type:Case Report
- Keywords:
Klinefelter syndrome;
Aneuploidy;
Intracranial germ cell tumor
- MeSH:
Adolescent;
Aneuploidy;
Carcinoma, Embryonal;
Delayed Diagnosis;
Gynecomastia;
Humans;
Hypogonadism;
Klinefelter Syndrome;
Korea;
Male;
Neoplasms, Germ Cell and Embryonal;
Pineal Gland;
Testis;
X Chromosome
- From:Clinical Pediatric Hematology-Oncology
2019;26(2):105-109
- CountryRepublic of Korea
- Language:English
-
Abstract:
Klinefelter syndrome (KS) is characterized by small testes, gynecomastia, tall stature, and hypergonadotropic hypogonadism. This condition is associated with extra X chromosomes. It is well known that these aneuploidies predispose individuals to the development of several cancers. Moreover, there are many case reports that show KS patients to have a higher relative risk for the development of malignancy. However, incracranial germ cell tumor (ICGCT) associated with KS is very uncommon. Herein, we report delayed diagnosis of KS in a 15-year-old boy with ICGCT, embryonal carcinoma of the pineal gland, after multimodality treatment in Korea.
