Two Cases of Cytomegalovirus Infection Developed in Pediatric Acute Lymphoblastic Leukemia Patients
10.15264/cpho.2019.26.2.115
- Author:
Nayoung JUNG
1
;
Donghyun KIM
;
Hee Seung CHIN
;
Soon Ki KIM
Author Information
1. Department of Pediatrics, Inha University Hospital, Incheon, Korea. pedkim@inha.ac.kr
- Publication Type:Case Report
- Keywords:
Cytomegalovirus;
Acute lymphoblastic leukemia
- MeSH:
Anti-Bacterial Agents;
Child;
Cytomegalovirus Infections;
Cytomegalovirus;
Drug Therapy;
Fever;
Ganciclovir;
Humans;
Liver;
Maintenance Chemotherapy;
Male;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Real-Time Polymerase Chain Reaction;
Retinitis
- From:Clinical Pediatric Hematology-Oncology
2019;26(2):115-118
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 14 year-old boy with acute lymphoblastic leukemia (ALL) on maintenance chemotherapy presented with vision-threatening cytomegalovirus (CMV) retinitis. Treatment with intavitreal ganciclovir injection (2 mg/0.1 mL) followed by oral ganciclovir resulted in successful resolution of CMV retinitis. Another 13 year-old boy with ALL on maintenance chemotherapy presented with prolonged fever with no response to antibiotics administration. CMV and real-time PCR revealed positive result and a titer of 2,618,700 copies/mL, respectively. Ganciclovir was used for more than the approved duration of treatment, but viral titer frequently recurred with elevated liver enzymes and fever. In these 2 cases of CMV infection, a high index of suspicion and prompt management is important in children receiving ALL chemotherapy.
