Antibiotic Sensitivity Patterns in Children with Urinary Tract Infection: Retrospective Study Over 8 Years in a Single Center
10.3339/jkspn.2019.23.1.22
- Author:
Byungwoo WOO
1
;
Youngkwon JUNG
;
Hae Sook KIM
Author Information
1. Department of Pediatrics, Daegu Fatima Hospital, Daegu, Korea. coreroo@hanmail.net
- Publication Type:Original Article
- Keywords:
Urinary tract infection;
Antibiotic sensitivity;
Extended-spectrum β-l actamase
- MeSH:
Amikacin;
Ampicillin;
Bacteria;
Child;
Daegu;
Humans;
Medical Records;
Prevalence;
Retrospective Studies;
Urinary Tract Infections;
Urinary Tract
- From:Childhood Kidney Diseases
2019;23(1):22-28
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We studied the pathogens and trends in antibiotic sensitivity pattern in children with urinary tract infection (UTI) over 8 years in order to evaluate adequate treatment. METHODS: We performed a retrospective review of medical records of children with UTI from January 2009 to December 2016 in Daegu Fatima Hospital. Uropathogens and antibiotic sensitivity patterns were selected. Only 1 bacterial species with a colony count of ≥105 CFU/mL was considered a positive result. We compared 2 periods group (A: 2009~2012, B: 2013~2016) to investigate trends of antibiotic sensitivity pattern. RESULTS: During the 8 year period, 589 cases are identified (E. coli was cultured in 509 cases, 86.4%). Among all patients, this study investigated the antibiotic sensitivity of E. coli . Antimicrobial susceptibility to ampicillin was steadily low for both periods (A: 32.6%, B: 40.1%, P=0.125), and to amikacin was consistently high for both periods (A: 99.4%, B: 99.3%, P=1.000). Antibiotic sensitivity to third-generation cephalosporin decreased from period A to B (A: 91.7%, B: 75.5%, P=0.000). Antibiotic sensitivity to quinolone significantly decreased from A to B (A: 88.4%, B: 78.2%, P=0.003). The prevalence of extended-spectrum β-lactamase-producing E. coli increased from period A to B (A: 6.1%, B: 17.1%, P=0.000). CONCLUSION: This study showed that conventional antibiotic therapy for the treatment of pediatric UTI needs to be reevaluated. A careful choice of antibiotic is required due to the change in antibiotic sensitivity and the emergence of antibiotic-resistant bacteria.
