Thyrotoxic hypokalemic periodic paralysis due to Graves' disease in 2 adolescents
10.6065/apem.2019.24.2.133
- Author:
Jung Gi ROH
1
;
Kyu Jung PARK
;
Hae Sang LEE
;
Jin Soon HWANG
Author Information
1. Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea. seaon98@naver.com
- Publication Type:Case Report
- Keywords:
Thyrotoxic periodic paralysis;
Hypokalemia;
Graves' disease
- MeSH:
Adolescent;
Antithyroid Agents;
Asian Continental Ancestry Group;
Child;
Follow-Up Studies;
Goiter;
Graves Disease;
Humans;
Hypertension;
Hypokalemia;
Hypokalemic Periodic Paralysis;
Leg;
Male;
Paralysis;
Potassium Chloride;
Tachycardia;
Thyrotoxicosis
- From:Annals of Pediatric Endocrinology & Metabolism
2019;24(2):133-136
- CountryRepublic of Korea
- Language:English
-
Abstract:
Thyrotoxic periodic paralysis (TPP) is a notable and potentially lethal complication of thyrotoxicosis, and Graves' disease is the most common cause of TPP. TPP is commonly reported in Asian males between 20–40 years of age, but it is rare in children and adolescents. We report 2 Korean adolescents (a 16-year-old male and a 14-year-old female) with episodes of TPP who were previously diagnosed with Graves' disease. These 2 patients presented with lower leg weakness in the morning after waking up. They were diagnosed with TPP-associated with thyrotoxicosis due to Graves' disease. After they were initially treated with potassium chloride and antithyroid drugs, muscle paralysis improved and an euthyroid state without muscle paralytic events was maintained during follow-up. Therefore, clinicians should consider TPP when patients have sudden paralysis and thyrotoxic symptoms such as goiter, tachycardia, and hypertension.
