The Significance of NOTCH Pathway in the Development of Fibrosis in Systemic Sclerosis
- Author:
Szymon ZMORZYŃSKI
1
;
Wojciech STYK
;
Agata Anna FILIP
;
Dorota KRASOWSKA
Author Information
- Publication Type:Review
- Keywords: Fibrosis; NOTCH genes; NOTCH pathway; Scleroderma; systemic; Transforming growth factor beta
- MeSH: Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Fibrosis; Hair Follicle; Heart; Keratinocytes; Kidney; Lung; Myofibroblasts; Scleroderma, Systemic; Sebaceous Glands; Skin; Transforming Growth Factor beta
- From:Annals of Dermatology 2019;31(4):365-371
- CountryRepublic of Korea
- Language:English
- Abstract: Systemic sclerosis (SSc) is an autoimmune disorder characterized by the fibrosis of skin, heart, lung, and kidney as well. Excessive activation of fibroblasts is associated with higher expression of Notch1 and/or Notch3 genes. The constitutive expression of NOTCH genes was described in epithelial cells: epidermal keratinocytes, hair follicle cells and sebaceous glands. The NOTCH signalling pathway may be involved in the development of fibrosis, myofibroblast formation and the process of epithelial-mesenchymal transition. Activation of the NOTCH pathway leads to morphological, phenotypic and functional changes in epithelial cells. Furthermore, inhibition of Notch signalling prevent the development of fibrosis in different models, among them, bleomycin-induced fibrosis and in the Task-1 mause model. Molecular mechanisms, including the role of NOTCH signaling pathway, associated with fibrosis in SSc have not been completely recognized.
