Anaphylaxis to Chlorpheniramine Maleate and Literature Review
- Author:
Yong Won CHOI
1
;
Min Je JUNG
;
Hye One KIM
;
Bo Young CHUNG
;
Chun Wook PARK
Author Information
- Publication Type:Case Report
- Keywords: Anaphylaxis; Chlorpheniramine; Histamine H1 antagonist; Intradermal tests; Urticaria
- MeSH: Adult; Anaphylaxis; Chlorpheniramine; Diagnosis; Dizziness; Female; Histamine Antagonists; Humans; Injections, Intramuscular; Intradermal Tests; Skin; Urticaria
- From:Annals of Dermatology 2019;31(4):438-441
- CountryRepublic of Korea
- Language:English
- Abstract: Chlorpheniramine maleate is commonly used antihistamine. Since antihistamines are the main therapeutic agents for symptomatic treatment of urticaria, anaphylaxis to antihistamines may lead to errors in diagnosis and treatment. We report a case of anaphylaxis induced by chlorpheniramine maleate confirmed by intradermal test. A 35-year-old female experienced history of anaphylaxis after intramuscular injection of chlorpheniramine maleate. Skin prick test was negative, but intradermal test was positive. Patient also experienced mild dizziness after intradermal test and refused to perform any further evaluation such as oral challenge test. Anaphylaxis for chlorpheniramine maleate is very rare but should be considered.
