Effect of Cardiac Rehabilitation on Outcomes in Patients with ST-Elevation Myocardial Infarction
10.3349/ymj.2019.60.6.535
- Author:
Hye Young LEE
1
;
Sung Jin HONG
;
In Hyun JUNG
;
Gwang Sil KIM
;
Young Sup BYUN
;
Byung Ok KIM
Author Information
1. Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. byungokim@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Cardiac rehabilitation;
myocardial infarction;
drug eluting stent
- MeSH:
Angiography;
Drug-Eluting Stents;
Follow-Up Studies;
Humans;
Myocardial Infarction;
Percutaneous Coronary Intervention;
Rehabilitation
- From:Yonsei Medical Journal
2019;60(6):535-541
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Whether cardiac rehabilitation (CR) improves clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) has not been thoroughly evaluated. Moreover, few studies have sought to identify patients who would benefit most from CR among STEMI patients. MATERIALS AND METHODS: Consecutively, 265 STEMI patients who underwent primary PCI with implantation of DESs and follow-up angiography were examined. Seventy-six patients (30%) who received CR were assigned to the CR+ group. Another 178 patients (70%) who did not participate in CR were assigned to the CR− group. Second generation DESs were implanted in 238 (94%) patients. RESULTS: Major adverse cardiovascular events (MACEs), including death, myocardial infarction, and revascularization, were compared. The CR+ group tended to have lower MACE than the CR− group at 3 years, although the difference was not statistically significant (9.9% vs. 18.3%, hazard ratio=0.54, p=0.138). Subgroup analysis revealed a significant interaction according to CR and preprocedural thrombolysis in myocardial infarction (TIMI) flow (p value for interaction=0.011). In patients with low preprocedural TIMI flow (TIMI flow ≤1, n=161), those in the CR+ group had significantly lower MACE than those in the CR− group (p=0.005), whereas MACE was not different among patients with higher TIMI flow (TIMI flow ≥2, n=93). CONCLUSION: CR including exercise training was associated with lower MACE, particularly in patients with lower preprocedural TIMI flow during primary PCI for STEMI in the current DES era.
