Prognostic Significance of Cigarette Smoking in Association with Histologic Subtypes of Resected Lung Adenocarcinoma
10.5090/kjtcs.2019.52.5.342
- Author:
Jung Hoon YI
1
;
Pil Jo CHOI
;
Sang Seok JEONG
;
Jung Hee BANG
;
Jae Hwa JEONG
;
Joo Hyun CHO
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea. pjchoi@dau.ac.kr
- Publication Type:Original Article
- Keywords:
Smoking;
Adenocarcinoma;
Lung neoplasms
- MeSH:
Adenocarcinoma;
Classification;
Humans;
Logistic Models;
Lung Neoplasms;
Lung;
Multivariate Analysis;
Prognosis;
Smoke;
Smoking;
Tobacco Products;
World Health Organization
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2019;52(5):342-352
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Smokers with lung adenocarcinoma have a worse prognosis than those who have never smoked; the reasons for this are unclear. We aimed to elucidate the impact of smoking on patients’ prognosis and the association between smoking and clinicopathologic factors, particularly histologic subtypes. METHODS: We reviewed the records of 233 patients with pathologic stage T1-4N0-2M0 lung adenocarcinomas who underwent surgery between January 2004 and July 2015. The histologic subtypes of tumors were reassessed according to the 2015 World Health Organization classification. RESULTS: In total, 114 patients had a history of smoking. The overall survival probabilities differed between never-smokers and ever-smokers (80.8% and 65.1%, respectively; p=0.003). In multivariate analyses, the predominant histologic subtype was an independent poor prognostic factor. Smoking history and tumor size >3 cm were independent predictors of solid or micropapillary (SOL/MIP)-predominance in the logistic regression analysis. Smoking quantity (pack-years) in patients with SOL/MIP-predominant tumors was greater than in those with lepidic-predominant tumors (p=0.000). However, there was no significant difference in smoking quantity between patients with SOL/MIP-predominant tumors and those whose tumors had non-predominant SOL/MIP components (p=0.150). CONCLUSION: Smoking was found to be closely associated with SOL/MIP-predominance in lung adenocarcinoma. Greater smoking quantity was related to the presence of a SOL/MIP component.
