Clinical Outcomes of Surgical Treatment for Primary Chest Wall Soft Tissue Sarcoma
10.5090/kjtcs.2019.52.3.148
- Author:
Seung Hwan YOON
1
;
Joon Chul JUNG
;
In Kyu PARK
;
Samina PARK
;
Chang Hyun KANG
;
Young Tae KIM
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. ikpark@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Chest wall;
Sarcoma;
Recurrence
- MeSH:
Follow-Up Studies;
Histiocytoma, Malignant Fibrous;
Humans;
Methods;
Multivariate Analysis;
Neoplasm Metastasis;
Proportional Hazards Models;
Recurrence;
Retrospective Studies;
Risk Factors;
Sarcoma;
Survival Rate;
Thoracic Wall;
Thorax
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2019;52(3):148-154
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study investigated the clinical outcomes of surgical treatment of primary chest wall soft tissue sarcoma (CW-STS). METHODS: Thirty-one patients who underwent surgery for CW-STS between 2000 and 2015 were retrospectively reviewed. The disease-free and overall survival rates were estimated using the Kaplan-Meier method, and prognostic factors were analyzed using a Cox proportional hazards model. RESULTS: The median follow-up duration was 65.6 months. The most common histologic type of tumor was malignant fibrous histiocytoma (29%). The resection extended to the soft tissue in 14 patients, while it reached full thickness in 17 patients. Complete resection was achieved in 27 patients (87.1%). There were 5 cases of local recurrence, 3 cases of distant metastasis, and 5 cases of combined recurrence. The 5-year disease-free rate was 49%. Univariate analysis indicated that incomplete resection (p<0.001) and stage (p=0.062) were possible risk factors for recurrence. Multivariate analysis determined that incomplete resection (p=0.013) and stage (p=0.05) were significantly associated with recurrence. The overall 5- and 10-year survival rates were 86.8% and 64.3%, respectively. No prognostic factor for survival was identified. CONCLUSION: Long-term primary CW-STS surgery outcomes were found to be favorable. Incomplete microscopic resection and stage were risk factors for recurrence.
