Combination of Magnetic Resonance Spectroscopy and ¹¹C-Methionine Positron Emission Tomography for the Accurate Diagnosis of Non-Enhancing Supratentorial Glioma
- Author:
Nijiati KUDULAITI
1
,
2
;
Tianming QIU
;
Junfeng LU
;
Huiwei ZHANG
;
Zhengwei ZHANG
;
Yihui GUAN
;
Dongxiao ZHUANG
;
Jinsong WU
Author Information
- Publication Type:Original Article
- Keywords: Glioma; Magnetic resonance spectroscopy; Methionine; PET
- MeSH: Diagnosis; Electrons; Glioma; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Methionine; Positron-Emission Tomography; Sensitivity and Specificity
- From:Korean Journal of Radiology 2019;20(6):967-975
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To evaluate whether the combination of magnetic resonance spectroscopy (MRS) and 11C-methionine positron emission tomography (11C-MET PET) could increase accurate diagnostic sensitivity for non-enhancing supratentorial gliomas. MATERIALS AND METHODS: Between February 2012 and December 2017, 109 patients with non-enhanced supratentorial lesions on contrast-enhanced MRI were enrolled. Each patient underwent MRS and 11C-MET PET before treatment. A lesion was considered to be a glioma when either the MRS or 11C-MET PET results reached the diagnostic threshold. The radiological diagnosis was compared with the pathological diagnosis or medical diagnostic criteria. RESULTS: The sensitivity and specificity were 60.0% and 50.0% for MRS and 75.8% and 50.0% for 11C-MET PET, respectively. Upon combining the two modalities, the sensitivity and specificity of the imaging-based diagnosis prior to surgery reached 89.5% and 42.9%, respectively. Statistically significant differences in the sensitivities were observed between the combined and individual approaches (MRS alone, 89.5% vs. 60.0%, p < 0.001; 11C-MET PET alone, 89.5% vs. 75.8%, p = 0.001). However, no significant differences in specificity were observed between the combined and individual modalities. CONCLUSION: The combination of MRS and 11C-MET PET findings significantly increases accurate diagnostic sensitivity for non-enhancing supratentorial gliomas without significantly lowering the specificity. This finding suggests the potential of the combined MRS and 11C-MET PET approach in clinical applications.
