Two Cases of Seronegative Paraneoplastic Neurologic Syndrome with Opsoclonus Nystagmus
10.3342/kjorl-hns.2018.00318
- Author:
Seong Hoon BAE
1
;
Jeon Mi LEE
;
Sung Huhn KIM
Author Information
1. Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea. fledermaus@yuhs.ac
- Publication Type:Case Report
- Keywords:
Myoclonus;
Nystagmus;
Opsoclonus-myoclonus syndrome;
Paraneoplastic syndrome, neurologic
- MeSH:
Brain;
Dizziness;
Humans;
Magnetic Resonance Imaging;
Myoclonus;
Ocular Motility Disorders;
Opsoclonus-Myoclonus Syndrome;
Paraneoplastic Syndromes, Nervous System;
Prevalence
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2019;62(6):355-360
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The dizziness associated with paraneoplastic neurologic syndrome is hard to diagnose clinically because the prevalence of disease is rare, and radiologic and serologic examination result may come out normal. Opsoclonus-myoclonus symdrome is a representative of classical paraneoplastic neurologic syndromes. In this paper, we report 2 cases of paraneoplastic neurologic syndromes with negative serologic auto-antibody test and no brain lesion on MRI. Both cases were eventually diagnosed through PET. Patients with opsoclonus-myoclonus type nystagmus should be evaluated for paraneoplastic neurologic syndrome even if their radiologic and serologic findings are normal.
