Acquired Reactive Perforating Collagenosis as a Preceding Manifestation of Hodgkin's Lymphoma
- Author:
Soo Young LEE
1
;
Chul Hwan BANG
;
Young Min PARK
;
Jun Young LEE
;
Ji Hyun LEE
Author Information
1. Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. ejee@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Acquired perforating disorder;
Acquired reactive perforating collagenosis;
Hodgkin's lymphoma
- MeSH:
Adult;
Biopsy;
Bleomycin;
Collagen;
Dacarbazine;
Dermis;
Diabetes Mellitus;
Diagnosis;
Doxorubicin;
Drug Therapy;
Epidermis;
Extremities;
Hodgkin Disease;
Humans;
Leg;
Neck;
Renal Insufficiency, Chronic;
Skin;
Vinblastine
- From:Korean Journal of Dermatology
2019;57(6):332-334
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 40-year-old man presented with pruritic, multiple, variable-sized, erythematous umbilicated papules on the trunk and both extremities for 4 months. He was diagnosed with Hodgkin's lymphoma (stage IIA) after histopathologic examination of a neck mass that developed a month ago. A punch biopsy was performed on his right lower leg. Histological examination showed transepidermal elimination of the degenerated collagen. Masson's trichrome staining was performed to distinguish collagen fibers from the muscular tissue; using Masson's stain, the collagen appeared as a bluish color crossing from the dermis to the epidermis. The diagnosis of acquired reactive perforating collagenosis was made. The skin lesions showed much improvement after 6 cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy. Acquired perforating disorders are a group of cutaneous disorders that occur in adults with chronic kidney disease or diabetes mellitus. Cases of acquired perforating disorders associated with Hodgkin's lymphoma have been rarely reported in the English literature. To our knowledge, this is the first case of acquired reactive perforating collagenosis in a Korean patient with Hodgkin's lymphoma.
