Formulation of the Scope and Key Questions of the Guideline Recommendations for Immunosuppressive Treatment in Kidney Transplantation
10.24304/kjcp.2019.29.1.18
- Author:
Seungyeon HUH
1
;
Nayoung HAN
;
Minji SOHN
;
Junghwa RYU
;
Jaeseok YANG
;
Jung Mi OH
Author Information
1. College of Pharmacy & Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea. hans1217@snu.ac.kr
- Publication Type:Practice Guideline
- Keywords:
Kidney transplantation;
clinical guideline;
evidence-based;
key questions
- MeSH:
Clinical Decision-Making;
Consensus;
Kidney Transplantation;
Kidney;
Korea;
Transplant Recipients
- From:Korean Journal of Clinical Pharmacy
2019;29(1):18-24
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Although a growing number of guidelines and clinical researches are available for immunosuppressive treatment of post-transplantation, there is no clinical practice guideline for the care of kidney transplant recipients in Korea. Selection of a researchable question is the most important step in conducting qualified guideline development. Thus, we aimed to formulate key questions for Korean guideline to aid clinical decision-making for immunosuppressive treatment. METHODS: Based on previous published guidelines review, a first survey was constructed with 29 questions in the range of immunosuppressive treatments. The experts were asked to rate the clinical importance of the question using a 5-point Likert scale. The questions reached 60% or more from the first survey and additional new questions were included in the second survey. In analyzing the responses to items rated on the 9-point scale, consensus agreement on each question was defined as 75% or more of experts rating 7 to 9. RESULTS: In the first survey, 50 experts were included. Among the 29 questions, 27 were derived to get 60% or more importance and 3 new questions were additionally identified. Through the second survey, 9 questions were selected that experts reached consensus on 75% and over of the options. Finally, we developed key questions using PICO (patient, intervention, comparison, and outcome) methodology. CONCLUSION: The experts reached a high level of consensus on many of key questions in the survey. Final key questions provide direction for developing clinical practice guideline in the immunosuppressive treatment of transplantation.
