Recent progress in studies of factors that elicit pancreatic β-cell expansion.
10.1007/s13238-014-0123-3
- Author:
Qiu LI
1
;
Zhi-Chun LAI
Author Information
1. Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China.
- Publication Type:Journal Article
- MeSH:
Cell Communication;
genetics;
Cell Differentiation;
genetics;
Cell Proliferation;
Diabetes Mellitus, Type 1;
genetics;
pathology;
Diabetes Mellitus, Type 2;
genetics;
pathology;
Humans;
Insulin-Secreting Cells;
chemistry;
metabolism;
pathology
- From:
Protein & Cell
2015;6(2):81-87
- CountryChina
- Language:English
-
Abstract:
The loss of or decreased functional pancreatic β-cell is a major cause of type 1 and type 2 diabetes. Previous studies have shown that adult β-cells can maintain their ability for a low level of turnover through replication and neogenesis. Thus, a strategy to prevent and treat diabetes would be to enhance the ability of β-cells to increase the mass of functional β-cells. Consequently, much effort has been devoted to identify factors that can effectively induce β-cell expansion. This review focuses on recent reports on small molecules and protein factors that have been shown to promote β-cell expansion.
