Regulation of TAZ in cancer.
10.1007/s13238-016-0288-z
- Author:
Xin ZHOU
1
;
Qun-Ying LEI
2
Author Information
1. Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology and Institutes of Biomedical Sciences, Fudan University Shanghai Medical College, Shanghai, 200032, China. XZhou8@mdanderson.org.
2. Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology and Institutes of Biomedical Sciences, Fudan University Shanghai Medical College, Shanghai, 200032, China. qlei@fudan.edu.cn.
- Publication Type:Journal Article
- Keywords:
TAZ;
cancer;
the Hippo pathway
- MeSH:
Animals;
Apoptosis;
Cell Differentiation;
Cell Proliferation;
Energy Metabolism;
genetics;
Epithelial-Mesenchymal Transition;
Humans;
Hypoxia;
genetics;
metabolism;
pathology;
Neoplasm Invasiveness;
Neoplasm Proteins;
genetics;
metabolism;
Neoplasms;
genetics;
metabolism;
pathology;
Osmotic Pressure;
Stress, Mechanical;
Transcription Factors;
genetics;
metabolism
- From:
Protein & Cell
2016;7(8):548-561
- CountryChina
- Language:English
-
Abstract:
TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene (WW domain containing transcription regulator 1). TAZ is tightly regulated in the hippo pathway-dependent and -independent manner in response to a wide range of extracellular and intrinsic signals, including cell density, cell polarity, F-actin related mechanical stress, ligands of G protein-coupled receptors (GPCRs), cellular energy status, hypoxia and osmotic stress. Besides its role in normal tissue development, TAZ plays critical roles in cell proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), and stemness in multiple human cancers. We discuss here the regulators and regulation of TAZ. We also highlight the tumorigenic roles of TAZ and its potential therapeutic impact in human cancers.
