The clinical application of time-of-flight mass spectrometry in nucleic acid detection
10.3760/cma.j.issn.1009-8158.2019.08.020
- VernacularTitle:飞行时间质谱核酸检测技术在临床检测中的应用
- Author:
Yun XU
1
;
Yun LI
;
Xiaoli ZHANG
;
Ji XU
;
Wenlan LIU
Author Information
1. 深圳大学附属第一医院 深圳市第二人民医院
- Keywords:
Spectrometry;
Mass;
Matrix assisted laser desorption / ionization(MALDI);
Gene polymorphism;
DNA methylation
- From:
Chinese Journal of Laboratory Medicine
2019;42(8):694-699
- CountryChina
- Language:Chinese
-
Abstract:
As a high-throughput, sensitive, accurate and convenient detection technology, matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) has been widely used in molecular diagnosis and research of various diseases. The in-depth application is outstanding, particularly in pharmacogenomics, tumor susceptibility gene detection, DNA methylation detection, diagnosis of hereditary diseases, genotyping and drug-resistance detection of bacteria and virus. MALDI-TOF has become an indispensable molecular diagnostic technology for precision medicine.
