Correlation of serum vitamin D level with metabolic syndrome in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2019.07.005
- VernacularTitle:2型糖尿病患者血清维生素D水平与代谢综合征的相关性研究
- Author:
Chuanwei LIU
1
;
Xiutao HONG
;
Yan YANG
;
Ziming MAO
;
Fengling CHEN
Author Information
1. 上海交通大学医学院附属第九人民医院内分泌科
- Keywords:
Vitamin D;
25-hydroxyvitamin;
Metabolic syndrome;
Diabetes mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(7):564-569
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] level and the risk of metabolic syndrome ( MS) and its components in patients with type 2 diabetes mellitus. Methods Clinical data of 796 type 2 diabetic inpatients in the Department of Endocrinology, the Ninth People' s Hospital, Shanghai Jiaotong University School of Medicine, from January 2017 to December 2018 were enrolled. These patients were divided into MS group (n=541) and non-MS group (n=255). The association of serum vitamin D level and metabolic syndrome was investigated. Results The level of 25( OH) D in MS group was significantly lower than that in non-MS group (P<0.05). According to 25(OH)D 20 ng/ml as the borderline of vitamin D deficiency, the rate of 25(OH)D deficiency in MS group was significantly higher than that in non-MS group (P<0.01). Serum 25(OH)D levels in patients with type 2 diabetes were negatively correlated with smoking, body mass index, systolic blood pressure, diastolic blood pressure, waist circumference, triglyceride, and low density lipoprotein-cholesterol levels ( all P<0.05) . Multiple logistic regression analysis showed that 25( OH) D was an independent protective factor for MS in patients with type 2 diabetes. These patients were divided into 4 subgroups according to 25( OH) D levels [ Q1:0-10 ng/ml (n=24), Q2:10-20 ng/ml (n=417), Q3:20-30 ng/ml (n=117), Q4≥30 ng/ml(n=18)]. Logistic regression showed that the risk ratios (OR) of the metabolic syndrome in the Q2, Q3, and Q4 groups were 0.471, 0.389, and 0.211 respectively, compared with Q1 group (P<0.05).Conclusion Serum 25(OH)D level in type 2 diabetic patients was negatively correlated with the risk of MS.
