Establishment and effect evaluation of a variety of radiation-induced lung injury animal models
10.3760/cma.j.issn.1004-4221.2019.06.017
- VernacularTitle:多种放射性肺损伤动物模型的建立和效应评价研究
- Author:
Runzhi QI
1
;
Jiangang LIU
;
Xianwen WU
Author Information
1. 中国中医科学院广安门医院肿瘤科
- Keywords:
Radiation-induced lung injury;
Animal model;
Dose volume relationship;
Model evaluation
- From:
Chinese Journal of Radiation Oncology
2019;28(6):472-475
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced lung injury (RILI) is a common complication after radiotherapy for thoracic tumors.It is one of the most urgent problems to explore the optimal animal model and evaluate the effect for basic research and drug intervention along with the extensive studies of radiation pneumonia.By reviewing the literatures published in recent 10 years,the selection of irradiation site,determination of irradiation dosage,irradiation method and effect evaluation were statistically compared among different RILI animal models,aiming to explore a stable method of establishing the animal model with RILI and identify a definite effect mechanism.It provides a reliable approach for basic research and drug development to prevent and mitigate the incidence and development of RILI.
