Adverse events of radiotherapy combined with immune checkpoint inhibitors
10.3760/cma.j.issn.0254-5098.2019.08.006
- VernacularTitle:放射治疗联合免疫检查点抑制剂的不良反应
- Author:
Fenghao SUN
1
;
Ligang XING
Author Information
1. 潍坊医学院261053;山东省肿瘤防治研究院山东省肿瘤医院山东第一医科大学山东省医学科学院
- Keywords:
Radiation therapy;
Immune checkpoint inhibitors;
Adverse events
- From:
Chinese Journal of Radiological Medicine and Protection
2019;39(8):594-598
- CountryChina
- Language:Chinese
-
Abstract:
Radiation therapy and immune checkpoint inhibitors(ICI) have a synergistic effect on anti-tumor,which involves a series of complex mechanisms of effects with the immune system,and can improve the clinical outcomes of cancer patients.However,the mechanism by which radiation therapy combined with ICI synergistically modulates the immune response may also trigger treatment-related adverse events.In view of the increasing number of clinical studies and practices of combination therapy,it is necessary to pay attention to the risk of adverse events in combination therapy of radiotherapy and ICI,so as to evaluate the safety of combination therapy.
