Application of thyroglobulin measurement in fine‐needle aspiration for detecting lymph node metastasis in papillary thyroid carcinoma
10.3760/cma.j.issn.1004‐4477.2019.04.007
- VernacularTitle:穿刺洗脱液甲状腺球蛋白测定在诊断甲状腺乳头状癌转移淋巴结中的应用
- Author:
Lili JI
1
;
Shuangquan JIANG
;
Shouqiang LI
;
Lei ZHANG
;
Dandan YU
;
Huan JI
;
Jiawei TIAN
;
Xiaoping LENG
Author Information
1. 哈尔滨医科大学附属第二医院超声医学科 150086
- Keywords:
Ultrasonography;
Fine‐needle aspiration cytology;
Papillary thyroid carcinoma;
Thyroglobulin;
Lymph node metastasis
- From:
Chinese Journal of Ultrasonography
2019;28(4):313-317
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of thyroglobulin measurement with fine‐needle aspiration ( FNA‐Tg ) in detecting papillary thyroid carcinoma ( PTC ) metastatic lymph nodes ,and analyze the impact of different factors on the diagnostic accuracy of FNA‐Tg . Methods One hundred and fifty‐four lymph nodes from 138 patients w ho underwent total thyroidectomy and cervical lymphadenectomy were enrolled . Ultrasonography ,fine needle aspiration cytology ( FNAC) and FNA‐Tg results were acquired in all patients . T he diagnostic value of FNAC ,FNA‐Tg and the combination of the two methods were compared in suspicious PTC metastatic lymph nodes . T he influence of lymph nodes size ,lymph nodes cystic change and serum thyroglobulin antibody( TgAb) on the accuracy of FNAC and FNA‐Tg were analyzed . Results T he sensitivities of FNAC ,FNA‐Tg ,and the combination of the two methods in the diagnosis were 79 .5% , 95 .5% and 97 .7% ,respectively . T he specificities were 100% ,93 .9% and 100% ,respectively . T he size and cystic change of lymph nodes had effects on the accuracy of FNAC( P ＜0 .05) ,w hile they had no effect on the accuracy of FNA‐Tg ( P ＝0 .42 ,0 .67 ) . T he serum TgAb level had no influence on the accuracy of FNAC and FNA‐Tg ( P ＝ 0 .88 ,0 .34 ) . Conclusions FNA‐Tg is sensitive to metastatic lymph nodes in PTC w hich not affected by the lymph nodes size ,the lymph nodes cystic change and serum TgAb level . Application of FNA‐Tg with FNAC can improve the sensitivity of diagnosis ,w hich is important in the diagnosis of PTC metastatic lymph nodes .
