Advances in adjuvant targeted therapy for non-small cell lung cancer
10.3969/j.issn.1000-8179.2018.23.173
- VernacularTitle:非小细胞肺癌辅助靶向治疗进展
- Author:
Dongsheng YUE
1
;
Changli WANG
Author Information
1. 天津医科大学肿瘤医院肺部肿瘤科
- Keywords:
non-small cell lung cancer (NSCLC);
adjuvant therapy;
targeted therapy
- From:
Chinese Journal of Clinical Oncology
2018;45(23):1225-1229
- CountryChina
- Language:Chinese
-
Abstract:
Currently, postoperative adjuvant chemotherapy is recommended for patients with stageⅡ-ⅢA non-small cell lung cancer (NSCLC). However, the toxicity of chemotherapy should not be neglected, despite the survival benefits achieved. There is an urgent need for new, effective, individualized treatment regimens with low toxicity. EGFR-TKI is widely used for the treatment of advanced NSCLC because of its high efficiency and low toxicity. To explore more effective treatment methodologies, researchers at home and abroad have made many attempts to extend targeted therapy to the field of postoperative adjuvant therapy. This article reviews the retrospective and prospective clinical studies that have been conducted, analyzes the preponderant population of postoperative adju-vant targeted therapy, and seeks evidence-based medical evidence to guide clinical practice, so that patients with NSCLC can benefit from targeted therapies and improved postoperative survival rates.
