Clinical significance of combined detection of PD-L1 protein and CD8 +TILs in resected lung adenocarcinoma
10.11904/j.issn.1002-3070.2019.01.007
- VernacularTitle:PD-L1蛋白与CD8+ TILs联合检测在可切除肺腺癌预后评估中的临床意义
- Author:
Jianli MA
1
;
Minghui ZHANG
;
Hongfei JI
;
Xiangying XU
Author Information
1. 哈尔滨医科大学附属肿瘤医院放射治疗科(哈尔滨 150081)
- Keywords:
Programmed cell death-ligand 1;
CD8high TILs;
Lung adenocarcinoma;
Prognosis
- From:
Practical Oncology Journal
2019;33(1):40-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective The prognostic role of PD-L1 expression in surgically resected lung adenocarcinoma(ADC)remains controversial. The aim of present study was to investigate the prognostic value of PD-L1 combined with CD8 +TILs expression in pa-tients with resectable lung adenocarcinoma. Methods A total of 104 patients with lung adenocarcinoma who underwent radical resec-tion were enrolled at the Affiliated Tumor Hospital of Harbin Medical University from January 2009 to December 2012. Immunohisto-chemistry was used to detect the expression of PD-L1 and CD8 +TILs in primary tumor specimens. Its clinical pathological factors and its relationship with prognosis were statistical analysis. Results The positive expression rate of PD -L1 in tumor cells was 38. 5% (40/104),and the positive rate of CD8 +TILs was 44. 2% (46/104). There was a significant correlation between the expres-sion of CD8 +TILs and TNM stages of patients with resectable ADC. The Kaplan-Meier survival analysis showed that low expression of PD-L1 and high expression of CD8 +TILs were significantly associated with disease -free survival ( DFS) and overall survival ( OS),and could be used as an independent predictors for predicting prognosis of patients with resectable ADC. Conclusion The ex-pression of PD-L1 and CD8 +TILs in the postoperative specimens can help to judge the prognosis of patients. This study has certain significance for immunotherapy of PD-1/PD-L1 pathway in patients with surgically resected ADC.
