Relationshipbetweenwhitematterintegrityandperipheralinterleukin10inschizophrenia
10.3969/j.issn.1002-1671.2019.07.001
- VernacularTitle:精神分裂症患者脑白质微结构改变与外周血白细胞介素10的关系
- Author:
Gui FU
1
;
Wenjing ZHANG
;
Jieke LIU
;
Yuan XIAO
;
Dongsheng WU
;
Su LÜ
Author Information
1. 四川大学华西医院放射科
- Keywords:
schizophrenia;
interleukin10;
magneticresonanceimaging
- From:
Journal of Practical Radiology
2019;35(7):1029-1033,1041
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toexploretherelationshipbetweenthemicrostructuralintegrityofwhitematter(WM)andperipheralinterleukin10 (IL-10)inschizophrenia.Methods Diffusion MRIdataandvenousbloodsampleswereacquiredfrom47schizophreniapatients(SZ) and49healthycontrols (HC).Tract-basedspatialstatisticswasconductedtoexaminethedifferencesinFAandradialdiffusivity (RD)betweentwogroups.QuantitativechemiluminescenceassaywasperformedtomeasureperipheralIL-10levels.Regressionanalysiswas conductedtoinvestigatetherelationshipbetweenperipheralIL-10levelsanddiffusion measures (FAandRD).Results Compared withHC,therewerewidespreadreductionsinFAandincreaseinRDinSZ.Additionally,comparedwith HC,peripheralIL-10levels werehigherinSZ.PeripheralIL-10wasnegativelycorrelatedwithFAintherightposteriorthalamicradiationandleftinferiorfronto-occipitalfasciculusamongthepatients(β=-0.51,P=0.01andβ=-0.47,P=0.02,respectively)butnotcontrols(β=-0.01,P=0.95 andβ=-00.03,P=09.8,respectively).Andthecorrelationcoefficientsofthetwogroupsweredifferent(z=25.0,P=00.1andz=23.7,P=00.2, respectively).Conclusion TheperipheralIL-10maycontributetothedisruptionsofmicrostructuralWMintegrityinschizophrenia, supportingthenotionforanimportantroleofinflammationinthepathogenesisofschizophrenia.
