Diagnostic value and prognostic evaluation of presepsin for acute respiratory distress syndrome (ARDS)
10.3969/j.issn.1672-8467.2019.03.011
- VernacularTitle:Presepsin在急性呼吸窘迫综合征(ARDS)中的诊断和预后评估价值
- Author:
Shan ZHANG
1
;
Qiong-Hua LIN
;
Li-Hua SHEN
;
Peng-Mei WANG
;
Zhong-Wei ZHANG
;
Yi-Jun ZHENG
;
Biao ZHU
Author Information
1. 复旦大学上海医学院肿瘤学系-复旦大学附属肿瘤医院麻醉科/重症医学科 上海200032
- Keywords:
presepsin;
soluble CD14 (sCD14);
acute respiratory distress syndrome (ARDS);
diagnosis;
prognosis
- From:
Fudan University Journal of Medical Sciences
2019;46(3):357-365,371
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the diagnostic and prognostic value of measuring presepsin in patients with acute respiratory distress syndrome (ARDS).Methods Plasma prsepsin was collected from 81 patients with ARDS,27 patients with cardiogenic pulmonary edema (CPE) and 20 healthy volunteers at enrollment.Levels of presepsin were measured using the PATHFAST(R) analysis system based on a chemiluminescent enzyme immunoassay (CLEIA).The differences of plasma prsepsin were compared between different groups.The 28-day mortality were followed in ARDS patients,and the characteristics of the surviors and non-surviors were compared.Results ARDS patients had significantly higher median levels of presepsin compared to CPE patients [926.89 (485.41-2 662.32)pg/mL vs.376.21 (247.16-568.52) pg/mL,P＜0.001] at enrollment.The difference between infected and non-infected ARDS patients did not showed statistical significance [(934.74 (456.44-3 322.51) pg/mL vs.798.12 (485.41-2 561.40) pg/mL,P--0.079).In ARDS patients,the presepsin levels of non-survivors was significantly higher than that of survivors [3 158.3 (963.91-4 489.33) pg/mL vs.729.09 (398.05-1 467.24) pg/mL,P＜0.001],and multivariate Logistic regression showed that presepsin (OR =1.51,P =0.027) was the independent predictor for 28-day mortality in ARDS patients with acute lung injury (ALI).Conclusions Presepsin was an effective indicator in diagnosing ARDS,and it also was a strong prognostic marker for short-term mortality in ARDS.
