Molecular alterations in precancerous lesions of esophageal squamous cell carcinoma
10.3760/cma.j.issn.1673-422X.2019.07.009
- VernacularTitle:食管鳞状细胞癌癌前病变的分子改变
- Author:
Chen CHANG
1
;
Mingrong WANG
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室
- Keywords:
Esophageal neoplasms;
Neoplasms;
squamous cell;
DNA;
RNA;
Proteins;
Precancerous lesions
- From:
Journal of International Oncology
2019;46(7):430-433
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal squamous cell carcinoma (ESCC)is one of the most predominant malignancies worldwide. ESCC develops gradually from the precancerous lesions. The researches about biomarkers mainly concentrate in the nucleic acid and protein,including cytogenetic abnormalities,amplifications,deletions,muta-tions,breakage and fusions of genomic DNA,expression changes of mRNA,microRNA (miRNA)and long non-coding RNA (lncRNA)in RNA level,and expression level,subcellular localization,and post-translational modi-fications of proteins. Studies on the molecular alterations in precancerous lesions and early cancer of the esopha-gus will contribute to the exploration of biomarkers for early diagnosis and intervention targets for this disease.
