Effect of histone deacetylase and its inhibitor on tumor
10.3760/cma.j.issn.1673-422X.2019.04.009
- VernacularTitle:组蛋白脱乙酰基酶及其抑制剂对肿瘤的作用
- Author:
Jing LIANG
1
;
Sha HAN
;
Jing YAO
;
Qingsheng KONG
Author Information
1. 曲阜师范大学生命科学学院
- Keywords:
Histone deacetylases;
Neoplasm metastasis;
Antineoplastic agents;
Histone deacetylase inhibitors
- From:
Journal of International Oncology
2019;46(4):235-238
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and progress of tumor is the result of the interaction of heredity and epigenetics. Histone deacetylation modification,as an important epigenetic modification,plays an important role in tumorigenesis and development. The abnormal expression of histone deacetylase in normal tissues and cells promotes the development of tumor and is related to the proliferation and apoptosis,angiogenesis,metastasis and drug resistance of tumor cells,and becomes a new target of tumor therapy. Histone deacetylase inhibitors as anti-tumor drugs have a good prospect of application.
