Regulating effect of lncRNA on aerobic glycolysis in tumor cells
10.3760/cma.j.issn.1673-422X.2019.03.008
- VernacularTitle:长非编码RNA在肿瘤细胞有氧糖酵解中的调控作用
- Author:
Chenyi ZHONG
1
;
Yundong MAO
Author Information
1. 南京医科大学第一附属医院生殖医学科 210029
- Keywords:
Neoplasms;
Glycolysis;
RNA,long noncoding
- From:
Journal of International Oncology
2019;46(3):170-173
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNA (lncRNA) is a kind of RNA with a length greater than 200 nucleotides and lacks protein-coding function.Varieties of lncRNAs have been found to play major roles in the aerobic glycolysis of tumor cells,such as lncRNA-p21,H19,prostate specific transcript 1 (PGCEM1) and so on.In tumor cells,lncRNA can directly regulate the rate-limiting enzyme in the glycolytic pathway,also can indirectly regulate the glycolysis by hypoxia inducible factor-1α (HIF-1α) or proto-oncogene c-myc.Further study on the mechanism of lncRNA regulating tumor cell glycolysis is expected to open up new ideas for the diagnosis and treatment of tumor diseases.
