Value of 18F-FDG PET-CT imaging features in the prognosis evaluation of newly diagnosed patients with multiple myeloma
10.3760/cma.j.issn.1009-9921.2019.08.002
- VernacularTitle:18F-FDG PET-CT显像特征在初诊多发性骨髓瘤患者预后评估中的价值
- Author:
Bing XIA
1
;
Ling WU
;
Mengzhen LI
;
Haifeng ZHAO
;
Xiaofang WANG
;
Yafei WANG
;
Yong YU
;
Yizhuo ZHANG
Author Information
1. 天津医科大学肿瘤医院血液科 国家肿瘤临床医学研究中心 天津市肿瘤防治重点实验室 天津市恶性肿瘤临床医学研究中心 300060
- Keywords:
Multiple myeloma;
Fluorodeoxyglucose F18;
Positron-emission tomography;
Laboratory examination;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2019;28(8):457-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relevance between 18F-FDG PET-CT imaging features and laboratory parameters of multiple myeloma (MM) and its prognostic value. Methods The clinical data of 75 MM patients who received 18F-FDG PET-CT examination at the time of initial diagnosis in Tianjin Medical University Cancer Institute & Hospital from September 2008 to August 2016 were retrospectively analyzed, including their clinical features, survival time, PET-CT imaging and laboratory results. The correlation between imaging changes and laboratory results was analyzed. Kaplan-Meier method and log-rank test were used to make survival analysis. Results Of 75 patients, there were 48 patients (64.0%) who had lytic bone lesions everywhere of the bodies, especially in axial skeleton. Twenty-six patients (34.7%) had pathological fracture, which were either rib or spinal pathologic fracture. PET-CT at initial diagnosis showed that the osteolytic lesions were associated with anemia (χ2＝ 0.455, P ＝ 0.032), while pathological fractures were associated with C-reactive protein levels (χ 2 ＝ 0.976, P ＝ 0.007). The existence of pathologic fracture or lytic bone lesions showed no relevance to abnormal cytogenetics, extramedullary lesion, lactic dehydrogenase, albumin or β2-macroglobulin (β2-MG) levels as well as the survival time (all P＞0.05). Twenty-eight patients (37.3%) with
