Progress of circulating tumor DNA in Bˉcell nonˉHodgkin lymphoma
10.3760/cma.j.issn.1009ˉ9921.2019.05.013
- VernacularTitle:循环肿瘤DNA在B细胞非霍奇金淋巴瘤中的研究进展
- Author:
Nini SONG
1
;
Lixia SHENG
;
Guifang OUYANG
Author Information
1. 宁波大学附属宁波市第一医院血液科 315000
- Keywords:
Lymphoma,nonˉHodgkin;
Circulating tumor DNA;
Molecular monitoring
- From:
Journal of Leukemia & Lymphoma
2019;28(5):306-309
- CountryChina
- Language:Chinese
-
Abstract:
Monitoring the disease status of the patients with nonˉHodgkin lymphoma (NHL) at the molecular level is of great significance in the accurate individualized management. The novel next generation sequencingˉbased methods enable the quantitative detection of circulating tumor DNA (ctDNA) in peripheral blood with great sensitivity, which can overcome the shortages of biopsies and imaging scans. As a new biomarker of NHL, ctDNA provides the opportunity for disease genotyping, prognosis evaluation, therapeutic response and recurrence monitoring, which may ultimately improve the prognosis of NHL patients.
