The relationship between Beclin 1 expression and lymph node metastasis in non-small cell lung cancer
10.7507/1007-4848.201902002
- VernacularTitle:非小细胞肺癌淋巴结 Beclin 1 表达与淋巴结转移的关系
- Author:
XIONG Jian
1
;
WU Lei
1
;
PI Yuyang
1
;
XU Yongdong
1
Author Information
1. Department of Thoracic Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, P.R.China
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
Beclin 1 gene;
lymph node metastasis
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2019;26(10):984-987
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between Beclin 1 level and lymph node metastasis in patients with non-small cell lung cancer. Method A total of 204 surgical specimens of patients with non-small cell lung cancer from September 2011 to September 2016 were collected in our hospital. There were 116 males and 88 females . Beclin 1 levels were detected by Western blotting. There were 116 males and 88 females at average age of 55.3±11.2 years. The patients were divided into three groups including a group N0 (no lymph node metastasis), a group N1(intralobar and interlobar lymph node metastases, and no mediastinal lymph node metastasis), and a group N2 (mediastinal lymph node metastasis). The differences of Beclin 1 levels in tumor tissues and lymph nodes of patients with N0, N1 and N2 were statistically analyzed. Results Among 204 patients of lung cancer, 36 patients were squamous cell carcinoma and 168 patients were adenocarcinoma. The levels of Beclin 1 in tumor tissues of N0, N1 and N2 groups decreased gradually with a statistical difference (P<0.05). In the three groups, the levels of Beclin 1 in the lung hilum and intrapulmonary lymph nodes (N1 Beclin 1) of N1 and N2 groups were less than that of N0 group with a statistical difference (P<0.01). In the three groups, the level of Beclin 1 in the mediastinal lymph nodes (N2 Beclin 1) of N2 group was less than that of the N0 and N1 groups with a statistical difference (P<0.01). In the N1 group, the level of N1 Beclin 1 was less than that of N2 group (P<0.01). In the N2 group, though the level of N1 Beclin 1 was less than N2 Beclin 1, there was no statistical difference (P>0.05). Conclusion Beclin 1 level can be used as a reference index to judge the benign and malignant lung masses, and lymph node Beclin 1 level can be used as an important reference index to help determine whether there is lymph node metastasis in lung cancer.
