A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin)
10.5415/apallergy.2018.8.e37
- Author:
Hirotake TAKAI
1
;
Izumi KATO
;
Kanako MITSUNAGA
;
Mayumi HARA
;
Takahiro KODAMA
;
Masaki KANAZAWA
;
Masaru TERAI
Author Information
1. Department of Pediatrics, Chiba Kaihin Municipal Hospital, Chiba 261-0012, Japan. takaihrt@icloud.com
- Publication Type:Case Report
- Keywords:
Anaphylaxis;
Anaphylactic shock;
Drug allergy;
Asverin;
Tipepidine hibenzate;
Child
- MeSH:
Anaphylaxis;
Child;
Common Cold;
Consciousness;
Cough;
Drug Hypersensitivity;
Erythema;
Humans;
Hypotension;
Male;
Respiratory Sounds;
Skin;
Urticaria;
Vomiting
- From:
Asia Pacific Allergy
2018;8(4):e37-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tipepidine hibenzate (Asverin) is commonly used as an antitussive drug for acute and chronic cough in various age groups and is generally safe and well-tolerated. However, we experienced a case of tipepidine hibenzate-induced anaphylactic shock in a 1-year-old boy. After ingesting cold medication including tipepidine hibenzate, the patient presented with generalized erythema and urticaria, swollen face, coughing, wheezing and vomiting, together with hypotension and a decreased level of consciousness. To identify the culprit drug, we performed skin prick tests (SPTs) and oral drug provocation tests (DPTs). SPTs revealed a negative reaction for all drugs, but DPTs caused a positive reaction only for a full therapeutic dose of tipepidine hibenzate. Physicians need to consider tipepidine hibezate as a culprit drug when anaphylaxis occurs after taking anticough or common cold medication.
