The impact of age on Pru p 3 IgE production in Italy
10.5415/apallergy.2017.7.1.42
- Author:
Giorgio CIPRANDI
1
;
Mara DE AMICI
;
Maria Luisa DI MARTINO
;
Fiorella BAROCCI
;
Paola COMITE
Author Information
1. Allergy and Laboratory Medicine Department, IRCCS-AOU San Martino-IST, 16132 Genoa, Italy. gio.cip@libero.it
- Publication Type:Original Article
- Keywords:
Pru p 3;
Lipid transfer protein;
Sensitization;
Age;
Italy
- MeSH:
Aging;
Food Hypersensitivity;
Immunoglobulin E;
Italy;
Pollen;
Prunus persica;
Retrospective Studies;
Rhinitis, Allergic, Seasonal
- From:
Asia Pacific Allergy
2017;7(1):42-47
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Pollen allergy may be frequently associated with fruit-vegetables: the so-called pollen food syndrome. Pru p 3 is the most relevant peach allergen. Previously, it has been reported that serum specific IgE level to Pru p 3 depends on age in a limited geographic area. OBJECTIVE: This study aimed to to test the hypothesis about the differences of Pru p 3 sensitization across Italy, mainly concerning the impact of age. METHODS: The current study was retrospective and multicentre, involving 2 labs in Northern Italy (709 subjects), 1 in Genoa (1,040 subjects), and 1 in Southern Italy (2,188 subjects). All of them referred to labs for IgE testing because of suspected food allergy. Serum IgE to Pru p 3 was assessed in all subjects. RESULTS: Sixteen point seven percent (16.7%) of subjects were sensitized to Pru p 3. Sensitization percentage sigificantly decreased over time. The serum IgE levels increased up to young adulthood and then decreased until aging. CONCLUSION: Our experience demonstrates that Pru p 3 sensitization and production are closely age-dependent phenomena.
