Clinical characteristics and long-term outcomes related to sputum eosinophilia in Korean asthmatics
10.5415/apallergy.2011.1.1.16
- Author:
Jae Woo JUNG
1
;
Sae Hoon KIM
;
Jae Woo KWON
;
Tae Wan KIM
;
Hye Ryun KANG
;
Heung Woo PARK
;
Sun Sin KIM
;
Yoon Seok CHANG
;
Sang Heon CHO
;
Kyung Up MIN
;
Cohort-For-Reality-And-Evolution-Of-Adult-Asthma (COREA)
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea. shcho@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Asthma;
Induced sputum;
Eosinophil;
Noneosinophilic asthma
- MeSH:
Adult;
Asthma;
Bronchial Provocation Tests;
Cohort Studies;
Eosinophilia;
Eosinophils;
Follow-Up Studies;
Forced Expiratory Volume;
Humans;
Lung;
Methacholine Chloride;
Phenotype;
Spirometry;
Sputum
- From:
Asia Pacific Allergy
2011;1(1):16-24
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Bronchial asthma is usually associated with high sputum eosinophil levels. However, recent reports have suggested the importance of noneosinophilic asthma (NEA) as a distinct phenotype of asthma. OBJECTIVE: The aim of this study was to evaluate clinical significance of sputum eosinophilia and long-term treatment outcomes related to sputum eosinophilia in Korean asthmatics. METHODS: A total of 201 steroid-naive asthmatics who had undergone induced sputum analysis at baseline were selected from the Cohort for Reality and Evolution of Adult Asthma study population. Clinical evaluation, spirometry, a skin-prick test, a methacholine bronchial provocation test, and sputum eosinophil analysis were performed initially, and patients received the treatment recommended by the Global Initiative for Asthma. Lung function was evaluated every 6 months, and 53 patients completed 24 months of regular follow-up visits. Sputum eosinophilia was defined as a sputum eosinophil count of >3%.
