Diagnosis value of microRNA-1 for acute myocardial infarction: A meta-analysis
10.7507/1007-4848.201810043
- VernacularTitle:MicroRNA-1 对急性心肌梗死诊断价值的系统评价与 Meta 分析
- Author:
YI Kang
1
,
2
;
MA Long
3
,
4
;
YOU Tao
1
,
2
;
XU Jianguo
3
,
4
;
HOU Xiaodong
1
,
2
;
WANG Dan
3
,
4
;
YANG Kexin
3
,
4
Author Information
1. Department of Cardiovascular Surgery, Gansu Provincial Hospital, Lanzhou, 730000, P.R.China;
2. The First Clinical Medical College of Lanzhou University, Lanzhou, 73000, P.R.China
3. The First Clinical Medical College of Lanzhou University, Lanzhou, 73000, P.R.China;
4. Congenital Heart Disease Diagnosis and Treatment Gansu Province International Science and Technology Cooperation Base, Lanzhou, 730000, P.R.China
- Publication Type:Journal Article
- Keywords:
MicroRNA-1;
myocardial infarction;
diagnosis;
meta-analysis
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2019;26(7):633-641
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the clinical value of miRNA-1 in the diagnosis of acute myocardial infarction (AMI) patients. Methods We searched PubMed, EMbase, Cochrane Library, CNKI, Wangfang, VIP, etc databases to identify literature about miRNA-1 in the diagnosis of AMI. Quality of the included literature was assessed by (quality assessment for diagnostic accuracy studies-2, QUADAS-2). The indices of pooled sensitivity (Sen), specificity (Spe), positivity likelihood ratio (PLR), negative likelihood ratio (NLR), diagnosis odds ratio (DOR), and the area under the summary receiver operating characteristic (SROC) curve were pooled using MetaDisc 1.4 software. Results A total of 12 articles were included. According to the different populations of miRNA-1 to be tested, subgroup analysis of healthy people (7 articles) and non-AMI disease groups (5 articles) was conducted. The results showed that AMI compared with healthy people, the pooled Sen was 0.78 with 95%CI 0.73 to 0.82, Spe was 0.88 with 95%CI 0.83 to 0.91 of miRNA-1 in the diagnosis of AMI. AUC of SROC curve was 0.911 2. Comparison of AMI and non-AMI patients, the pooled Sen was 0.59 with 95%CI 0.54 to 0.64, Spe was 0.74 with 95%CI 0.68 to 0.79 of miRNA-1 in the diagnosis of AMI. AUC of SROC curve was 0.743 2. Conclusion MiRNA-1 has a certain value in the diagnosis of AMI. It has an advantage in identifying AMI and patients with other systemic diseases, and can be combined with other biomarkers to diagnose AMI.
