Expression of matrix metalloproteinase-1, E26 transformation-specific-1 in laryngeal carcinoma tissue and the clinical significance.
- Author:
Chunli LIU
1
;
Shenglin ZHANG
;
Guiqin MA
;
Junwei LIANG
;
Junlan HU
Author Information
1. Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Chengde Medical College, Chengde, 067030, China. lch19245@sina.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Matrix Metalloproteinase 1;
metabolism;
Middle Aged;
Proto-Oncogene Protein c-ets-1;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2011;25(24):1111-1114
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of matrix metalloproteinase-1 (MMP-1), E26 transformation-specific-1 (Ets-1) in laryngeal carcinoma and to discuss their relevance and the roles in carcinogenesis and development of laryngeal carcinoma.
METHOD:Immunohistochemical technique was used to detect the expression of MMP-1 and Ets-1 protein in 34 tissues of laryngeal carcinoma and 34 para-carcinoma tissues, 15 cases of vocal cord polyps, and the use of the pathological image analysis software, we analysis the results of immunohistochemical semi-quantitatively.
RESULT:(1) The expression of MMP-1 and Ets-1 protein in laryngeal carcinoma tissues is obviously higher than that in para-carcinoma and in vocal cord polyps respectively (P < 0.05). There is no significant difference between the expression of para-carcinoma and vocal cord polyps(P > 0.05). (2) The expression of MMP-1, Ets-1 protein isn't related to patients' age and sex, tumor size,clinical classification (P > 0.05), but related to pathological grade, clinical stage and lymph nodes metastasis (P < 0.05). (3) There is a positive correlation between the expression of MMP-1 and Ets-1 in laryngeal carcinoma.
CONCLUSION:Overexpression of MMP-1 and Ets-1 was observed in laryngeal carcinoma. The high expression of MMP-1 and Ets-1 may contribute to the carcinogenesis and development of laryngeal carcinoma,which is a important value to judge the malignant degree and progress of laryngeal carcinoma.
