Expressions and correlation of HPA, CK2beta and HIF-1alpha in nasopharyngeal carcinoma.
- Author:
Qilong ZHONG
;
Shuangle WANG
;
Changwei LI
;
Chu YANG
;
Xin LIN
;
Xin LIN
;
Hangui LU
- Publication Type:Journal Article
- MeSH:
Carcinoma;
Casein Kinase II;
metabolism;
Female;
Heparin Lyase;
metabolism;
Humans;
Hypoxia-Inducible Factor 1, alpha Subunit;
metabolism;
Male;
Middle Aged;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Neoplasm Staging
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(3):157-161
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of HPA, CK2beta and HIF-1alpha gene in nasopharyngeal carcinoma (NPC) tissues, and the correlation between their expression with the clinical characteristics of NPC and the relativity of HPA, CK2beta and HIF-1alpha gene in NPC tissues.
METHOD:HPA, CK2beta and HIF-1alpha were detected with Super-Vision immunohistochemical method using antibody in 49 NPC specimens and 30 specimens with chronic nasopharyngitis tissue (CNT).
RESULT:The expression of HPA, CK2beta and HIF-1alpha in NPC tissue were significantly higher than those in CNT tissue (P<0.05, separately). The expression of HPA, CK2beta and HIF-1alpha were significantly related to the TNM stage and whether recurrence or metastasis occur after treatment (P<0.05, separate ly), but there was no obvious correlation between its expression and the sex of NPC patient (P>0.05). The expression of HIF-1alpha was significantly related to the age of NPC patient (P<0.05), while HPA, CK2beta were not. The expression of HPA, CK2beta and HIF-1alpha in NPC tissue was positively correlated with each other (P<0.05, separately).
CONCLUSION:HPA, CK2beta and HIF-1alpha play synergetic role in development of NPC, which plays an important role in invasiveness,recurrence and metastasis of NPC. There could be a positive cooperation among HPA, CK2beta and HIF-1alpha in the carcinogenesis and development of NPC.
