Denervation change of tensor veli palati in obstructive sleep apnea hypopnea syndrome.
- Author:
Yifang YANG
1
;
Xian ZHANG
;
Xianming CHEN
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Fuzhou General Hospital of PLA, Nanjing Military Region, Fuzhou, 350025, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Denervation;
Humans;
Male;
Middle Aged;
Palatal Muscles;
innervation;
Sleep Apnea, Obstructive;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(21):977-983
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the denervation change of Tensor Veli Palati in patients with OSAHS by determine the mRNA and protein expression of NCAM.
METHOD:The OSAHS group was consisted of 30 OSAHS patients and the normal control group was consisted of 10 chronic tonsillitis patients without OSAHS. Real-time quantitative RT-PCR and Western blot methods were used to determine the NCAM expression in specimens.
RESULT:(1) The mRNA and protein expression level of NCAM in the OSAHS group increased significantly compared with that in control group (P < 0.05). (2) There was positive correlation between AHI and the protein expression level of NCAM in the OSAHS group (r = 0.803, P < 0.01).
CONCLUSION:These results indicate that the denervation change of tensor veli palati appear in OSAHS patients, and the severity of OSAHS are relevant with the degree of denervation.
