Expression and correlation of cyclooxygenase-2 and vascular endothelial growth factor in nasopharyngeal carcinoma-.
- Author:
Weiqi BAI
1
;
Baohua HU
;
Jianguo TANG
;
Xuan LI
;
Rong HUANG
;
Jixia YU
;
Liping GU
Author Information
1. Department of Otorhinolaryngology, Second Hospital of Ningbo, Ningbo 315000, China. baiweiqi1117@gmail.com
- Publication Type:Journal Article
- MeSH:
Carcinoma;
Cyclooxygenase 2;
metabolism;
Humans;
Immunohistochemistry;
Lymphatic Metastasis;
Mucous Membrane;
metabolism;
Nasopharyngeal Carcinoma;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Nasopharyngitis;
metabolism;
Neoplasm Proteins;
metabolism;
Receptors, Vascular Endothelial Growth Factor;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(9):408-410
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the Expression and correlation of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor receptor (VEGF) in nasopharyngeal carcinoma.
METHOD:In this study, expression levels of COX-2, VEGF were examined in 58 patients with nasopharyngeal carcinoma and 38 patients with inflammation in nasopharyngeal mucosa by immunohistochemistry method.
RESULT:The expression of COX-2, VEGF were higher in nasopharyngeal carcinoma than those in nasopharyngeal mucosa (P < 0.05), and they had some correlation with the invasion and lymphatic metastasis and with the clinical stage of nasopharyngeal carcinoma (P < 0.05). The expression of COX-2 was positively correlated with that of VEGF (P < 0.05).
CONCLUSION:The coexpression of COX-2 and VEGF may play animportant role in the carcinogenesis and development of nasopharyngeal carcinoma, and they may prom (see text) lymph node metastasis of nasopharyngeal carcinoma.
