Clinical significance of SKP2 and MRP-1/CD9 expression in glottic carcinoma and adjacent tissues.
- Author:
Yan WANG
1
;
Yan SUN
;
Wenhai SUN
;
Zhijun CHEN
;
Fengmiao AN
Author Information
1. Department of Otorhinolaryngology, the Affiliated Hospital of Medical College of Qingdao University, Qingdao, 266003, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Antigens, CD;
metabolism;
Female;
Glottis;
pathology;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Membrane Glycoproteins;
metabolism;
Middle Aged;
Neoplasm Staging;
Neoplasms, Squamous Cell;
metabolism;
pathology;
S-Phase Kinase-Associated Proteins;
metabolism;
Tetraspanin 29
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(4):158-165
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of SKP2 and MRP-1/CD9 protein in glottic cancer and adjacent tissues, and to analyze its significance for a safe surgical margin.
METHOD:Thirty-eight cases of glottic squamous cell carcinoma were studied for its cancer tissue, tissue 2 mm, 5 mm, and 10 mm away from cancer, and 10 cases of vocal cord polyp were served as control. SKP2 and MRP-1/CD9 protein were examined by immunohistochemical method.
RESULT:The positive expression of SKP2 proteins decreased in sequence of polyp mucosa, those adjacent to carcinoma (10 mm, 5 mm, 2 mm ) and cancer tissue, and there was significant difference between them (P < 0.05); On the contrary, the positive expression of the MRP-1/CD9 proteins increased in sequence of polypous mucosa, those adjacent to carcinoma (10 mm, 5 mm, 2 mm) and cancer tissue,and there was significant difference between them (P < 0.05).
CONCLUSION:SKP2 and MRP-1/CD may act as the reference index for judging the biological specialty of LSCC. It is appropriate to regard 5 mm or above 5 mm away from tumors as a safe margin for surgical treatment of glottic carcinoma.
