Progress of circulating-tumor DNA in the precise medicine for advanced-stage cancer
10.3760/cma.j.issn.1009-9158.2019.03.006
- VernacularTitle:循环肿瘤DNA在中晚期肿瘤精准医疗中的应用进展
- Author:
Kecheng LI
1
;
Yang HU
;
Lin LI
;
Zhilin REN
;
Li JIANG
Author Information
1. 电子科技大学医学院
- Keywords:
Circulating tumor DNA;
Neoplasms;
Precision medicine;
Biomarkers,tumor
- From:
Chinese Journal of Laboratory Medicine
2019;42(3):176-180
- CountryChina
- Language:Chinese
-
Abstract:
Circulating tumor DNA (ctDNA) detection is one of "liquid biopsy"analysis. It has shown promising clinical application in cancer precise medicine due to its noninvasive sampling and real-time observation. Nowadays, ctDNA analysis has been clinically validated and successfully applied in advanced cancer, including selecting personalized treatment, monitoring treatment responses, minimal residual disease and recurrence. Although there has been rapidly increasing interests in ctDNA, its clinical application in cancer precise medicine is still facing few challenges, especially in screening and diagnosing cancer at early stages. Here, the latest progress in the applications and challenges of ctDNA in advancedstage tumor therapy were reviewed to provide references for future studies on ctDNA.
