Autologous peripheral blood stem cell transplantation for POEMS syndrome
10.3760/cma.j.issn.0578-1426.2019.03.011
- VernacularTitle:自体外周血造血干细胞移植治疗POEMS综合征
- Author:
Lisheng LIAO
1
;
Zhihai ZHENG
;
Shuang QU
;
Tiannan WEI
;
Ying XIE
;
Yun LIN
;
Biyun CHEN
;
Weimin CHEN
Author Information
1. 福建医科大学 省立临床医学院 福建省立医院血液科
- Keywords:
POEMS syndrome;
Peripheral blood stem cell transplantation;
Melphalan;
Lenalidomide
- From:
Chinese Journal of Internal Medicine
2019;58(3):209-212
- CountryChina
- Language:Chinese
-
Abstract:
Six patients with POEMS syndrome who received autologous peripheral blood stem cell transplantation (auto-PBSCT) were retrospectively analyzed.Conditioning regimen was high dose melphalan.Peripheral blood stem cells were collected after mobilization with cyclophosphamide (CTX) and growth factors.One patient presenting hydrothorax and ascites was treated with 3 cycles of lenalidomide and dexamethasone before mobilization.Auto-PBSCT was fairly tolerable.Hematopoietic reconstitution was successful in all patients without transplantation-related mortality.A decrease or normalization of serum vascular epithelial growth factor (VEGF) was observed in all patients at 3 months after transplantation.The neurological remission was seen in 5/6 patients.
