The role of whole brain radiation therapy in treatment of primary central nervous system lymphoma: necessary or not
10.3760/cma.j.issn.1004-4221.2019.03.013
- VernacularTitle:全脑放疗在原发中枢神经系统淋巴瘤治疗中的是是非非
- Author:
Liqun WEI
1
;
Liu YANG
;
Yu LIU
;
Junhong ZHANG
;
Conghua XIE
;
Yunfeng ZHOU
Author Information
1. 武汉大学中南医院放化疗科 430071
- Keywords:
Lymphoma/radiotherapy;
Whole brain radiation therapy;
Lymphoma/chemotherapy;
Methotrexate;
Neurotoxicity
- From:
Chinese Journal of Radiation Oncology
2019;28(3):222-225
- CountryChina
- Language:Chinese
-
Abstract:
Primary central nervous system lymphoma (PCNSL) is a type of extranodal non-Hodgkin lymphoma.Whole brain radiation therapy (WBRT) combined with high-dose methotrexate is the standard treatment.Although PCNSL patients are sensitive to radiation therapy,the duration of response is relatively short and it is likely to provoke delayed neurotoxicity,especially in the elderly patients.Reduced-dose WBRT and autologous stem cell transplantation (ASCT) can lower the risk of neutotoxicity,whereas the clinical efficacy remains to be validated.For the elderly patients with PCNSL,application of WBRT in the first-line treatment should be cautiously considered.
