Significance of T-cell dot test and combined detection of adenosine deaminase in tuberculous pleurisy at different ages
10.3760/cma.j.issn.1008-6315.2019.02.011
- VernacularTitle:结核性胸膜炎不同年龄段经结核感染T细胞斑点试验及腺苷脱氨酶联合检测的意义
- Author:
Zhihua ZHANG
1
;
Aizhen LI
;
Guiyun ZHU
;
Xiaoying AN
;
Hongyi FU
Author Information
1. 河北省胸科医院结核科
- Keywords:
Tuberculous pleurisy;
T cell enzyme-linked immuno-spot assay;
Adenosine deaminase;
Age
- From:
Clinical Medicine of China
2019;35(2):142-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical value of combined detection of tuberculous T cell enzyme-linked immuno spot assay (T-SPOT.TB) and adenosine deaminase (ADA) in tuberculous pleurisy patients of different ages.Methods From February 2014 to February 2018,three hundred and thirty-six patients with pleural effusion were admitted to Hebei Thoracic Hospital.Among them,two hundred and fifty five cases were diagnosed as tuberculous pleurisy and 81 cases were diagnosed as non-tuberculous pleurisy.The patients were divided into two groups according to their age.The younger group (214 cases) was 16-59 years old and the older group (122 cases) was over 60 years old.The sensitivity and specificity of T-SPOT.TB combined with ADA in the diagnosis of tuberculous pleurisy were compared between the two groups.Results The sensitivity and specificity of T-SPOT.TB were 85.5％ (153/179) and 71.4％ (25/35) in the young and middle-aged group,73.7％ (56/76) and 58.7％ (27/46) in the old group,respectively.The sensitivity of the young and middle-aged group was significantly higher than that of the old group (x2 =4.990,P =0.045).The sensitivity and specificity of T-SPOT.TB combined with ADA were 98.9％ (177/179) and 94.3％ (33/35) in the young and middle-aged group,96.1％ (73/76) and 89.1％ (41/46) in the elderly group,respectively.There was no significant difference in sensitivity and specificity between the two groups (x2 =0.256,P=0.393、x2=0.655,P=0.218).Conclusion The diagnostic efficacy of T-SPOT.TB combined with ADA in patients with tuberculous pleurisy at different ages has been improved,especially for those who can not tolerate pleural biopsy and elderly patients.
